Is Osteoarthritis an Autoimmune Disease? Causes, Symptoms & Professional Advice

Discover whether osteoarthritis is an autoimmune disease, and explore symptoms, causes and professional insights from a Osteopath.

osteoarthritis an autoimmune disease

Osteoarthritis affects millions across the UK, leading many to wonder: is osteoarthritis an autoimmune disease? In this in‑depth guide, we’ll clarify osteoarthritis, compare it to autoimmune conditions, and discuss evidence‑based care options—including insights from a Osteopath. For clarity, we’ve included transition words and referenced authoritative UK sources such as the NHS, NICE and the ASA to ensure reliable, compliant information.

Understanding Osteoarthritis

Firstly, osteoarthritis is the most common form of arthritis, characterised primarily by degeneration of joint cartilage and underlying bone. Contrary to some misconceptions, it is a wear‑and‑tear condition rather than an autoimmune disorder. According to the NHS:

“Osteoarthritis is a common condition that causes pain and inflammation in a joint. It occurs when the protective cartilage that cushions the ends of your bones gradually wears away.”

Moreover, the National Institute for Health and Care Excellence (NICE) defines osteoarthritis as a “clinical syndrome of joint pain accompanied by varying degrees of functional restriction”. Therefore, understanding its aetiology is critical to distinguishing it from autoimmune diseases.

Autoimmune Diseases vs Degenerative Joint Disease

Transitioning from definitions, it’s essential to highlight the difference between autoimmune disorders and degenerative conditions:

  • Autoimmune diseases occur when the body’s immune system mistakenly attacks healthy tissue. Examples include rheumatoid arthritis, lupus and multiple sclerosis.
  • Degenerative joint diseases like osteoarthritis result from mechanical stress, ageing, genetics, and metabolic factors that degrade joint cartilage over time.

Consequently, while both conditions can involve joint pain and stiffness, their underlying mechanisms differ markedly.

Is Osteoarthritis an Autoimmune Disease?

In short, no—osteoarthritis is not classified as an autoimmune disease. Whereas autoimmune arthritis (e.g., rheumatoid arthritis) involves an immune‑mediated attack on synovial tissue, osteoarthritis arises from mechanical and biochemical changes within the joint:

  1. Cartilage breakdown: Repetitive stress and age‑related changes lead to cartilage erosion.
  2. Bone remodelling: Subchondral bone reacts to stress, forming osteophytes (bone spurs).
  3. Low‑grade inflammation: Although inflammation occurs, it is secondary to mechanical damage, not driven by autoantibodies.

Furthermore, inflammatory markers in osteoarthritis are generally lower than in autoimmune arthritis, reinforcing that osteoarthritis is primarily degenerative.

osteoarthritis an autoimmune disease

Inflammatory Processes in Osteoarthritis

However, to add nuance, inflammation indeed plays a role in osteoarthritis progression:

  • Cytokine release: Damaged cartilage and bone release pro‑inflammatory cytokines (e.g., IL‑1, TNF‑α).
  • Synovitis: The joint’s lining, known as the synovium, can become inflamed, contributing to pain and swelling.
  • Chronic low-grade inflammation differs from the persistent, systemic inflammation characteristic of autoimmune conditions.

Nevertheless, the immune response in osteoarthritis remains localised and reactive rather than autoimmune.

Risk Factors and Prevalence

Understanding who is most at risk helps clarify its non‑autoimmune nature. Key risk factors include:

  • Age: Prevalence increases with age; most people over 60 show some signs on imaging.
  • Genetics: A family history of joint disease increases the risk.
  • Obesity: Excess weight increases the mechanical load on weight‑bearing joints.
  • Repetitive joint use: Occupations or sports with high joint strain—such as long‑distance running—can accelerate wear.
  • Previous injury: Joint damage from trauma predisposes to early osteoarthritis.

By contrast, autoimmune conditions often affect younger individuals and present with systemic symptoms (e.g., fever, fatigue), which are absent in primary osteoarthritis.

Signs, Symptoms & Diagnosis

Clinically, osteoarthritis presents with:

  • Joint pain: Worsens with activity and improves with rest.
  • Stiffness: Especially after periods of inactivity (e.g., first thing in the morning or after sitting).
  • Reduced range of motion: Joint mobility may become limited.
  • Crepitus: A crackling or grating sensation in the joint.

Diagnosis typically involves:

  1. Clinical assessment: History and physical examination by a GP or specialist.
  2. Imaging: X‑rays reveal joint space narrowing, osteophytes and subchondral sclerosis.
  3. Exclusion of other causes: Blood tests (e.g., rheumatoid factor) rule out autoimmune arthritis.

Additionally, patient‑reported outcome measures (e.g., WOMAC index) help quantify pain and function.

Treatment Overview

Next, explore evidence‑based treatments, ranging from lifestyle changes to professional interventions. Importantly, all claims about therapies must be substantiated and in line with ASA guidelines for osteopathy and chiropractic care.

osteoarthritis an autoimmune disease

1. Self‑Management & Lifestyle

Firstly, patients are encouraged to adopt:

  • Weight management: Reducing BMI lowers joint stress.
  • Regular low‑impact exercise: Swimming, cycling and walking maintain joint mobility and strengthen muscles.
  • Balanced diet: Anti‑inflammatory foods (e.g., omega-3-rich fish, fruits, vegetables) support joint health.

Moreover, pacing activities and using heat or cold packs can help manage flare‑ups.

2. Pharmacological Interventions

When self‑care is insufficient, medications may include:

  • Analgesics: Paracetamol for mild pain.
  • NSAIDs: Ibuprofen or naproxen reduce pain and inflammation but carry gastrointestinal and cardiovascular risks.
  • Topical agents: NSAID gels applied directly to the joint.
  • Intra‑articular injections: Corticosteroids or hyaluronic acid are administered under clinical guidance for more severe cases.

Using these under a GP’s supervision to monitor side effects is vital.

3. Role of a Chiropractor

A Chiropractor specialises in spinal and musculoskeletal adjustments. Although chiropractic manipulation cannot reverse cartilage loss, research indicates:

  • Pain relief: Manual therapies can improve pain and function in knee and hip osteoarthritis.
  • Postural improvement: Adjustments may relieve compensatory strain on adjacent joints.
  • Complementary approach: Best used alongside exercise and weight‑management programmes.

However, per ASA rules, chiropractors should avoid making disease‑cure claims and instead position their services as supportive of musculoskeletal health.

4. Role of an Osteopath

An Osteopath uses hands‑on techniques—such as soft‑tissue stretching, joint mobilisations and muscle energy techniques—to:

  • Enhance joint mobility By improving circulation and reducing muscle tension.
  • Alleviate pain: Through targeted manual therapy.
  • Encourage self‑management: Advising tailored exercises and ergonomic advice.

Importantly, in compliance with the ASA, osteopaths should not claim to cure osteoarthritis but to provide symptom relief and support functional improvement.

5. Advanced & Surgical Options

For refractory cases:

  • Physiotherapy: Tailored exercise regimens to improve strength and proprioception.
  • Orthotic devices: Braces or shoe inserts redistribute the load.
  • Surgical referral: Joint replacement (arthroplasty) for end‑stage disease delivers significant pain relief and functional restoration.

Surgeries carry risks and require a thorough pre‑operative assessment by an orthopaedic team.

When to Seek Professional Advice

Consequently, patients should consult a healthcare provider if they experience:

  • Persistent pain or swelling unresponsive to self‑care.
  • Rapidly worsening symptoms over weeks.
  • Signs of infection (e.g., fever, redness around a joint).
  • Functional decline that impacts daily activities.

A GP can facilitate referrals to physiotherapy, rheumatology or surgical teams.

Supporting Your Journey

Finally, living well with osteoarthritis involves a multidisciplinary approach. Working with a Chiropractor or Osteopath can complement medical and lifestyle strategies, helping to:

  • Maintain mobility
  • Reduce pain
  • Improve overall quality of life

For reliable patient leaflets and further reading, visit:

Conclusion

To conclude, osteoarthritis is not an autoimmune disease but a degenerative joint condition with secondary inflammatory features. By understanding its causes, symptoms and evidence‑based treatments—and by engaging qualified professionals such as a Chiropractor or Osteopath within the scope of their practice—you can effectively manage symptoms and maintain an active lifestyle. Always seek personalised advice from your GP before embarking on any new treatment plan.